O'Shea Lab - Salk Institute
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Exit of the pre-TCR from the ER/cis-Golgi is necessary for signaling differentiation, proliferation, and allelic exclusi...

Clodagh O'Shea Thornell, Ap Rosewell, Ir Hayes, B Owen, Mj

Published in Immunity

A major issue is whether surface expression of the pre-TCR is necessary for signaling the development of immature thymocytes. To address this question, we generated transgenic mice expressing a TCRbeta chain that had a strong endoplasmic reticulum (ER) retrieval signal (TCRbetaER) and that was expressed intracellularly but failed to reach the cell ...

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