Adenovirus E4ORF1-Induced MYC Activation Promotes Host Cell Anabolic Glucose Metabolism and Virus Replication
Published in Cell Metabolism
Upon infection, viruses exploit the host cell’s machinery to reprogram cellular metabolism for virus progeny generation. Thai et al. show that adenovirus reprograms host cell glucose metabolism via E4ORF1-induced MYC activation, which enhances glycolytic flux and enables nucleotide biosynthesis from glucose metabolites to promote optimal viral repl...
