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Adenovirus overrides cellular checkpoints for protein translation.

Clodagh O'Shea Choi, S Mccormick, F Stokoe, D

mTOR is a critical regulator of protein translation, and plays an important role in controlling cellular replication. Recent studies indicate that nutrient and growth factor mediated activation of mTOR is deregulated in human cancer, and therefore represents an attractive tumor target. However, activation of mTOR is a complex process that is not ye...

Modulation of the ARF-p53 pathway by the small DNA tumor viruses.

Clodagh O'Shea Fried, M

Published in Cell Cycle

The small DNA tumor viruses encode proteins that subvert many of the pivotal growth regulatory pathways within the cell to facilitate their own replication. The cell responds to viral infection/proteins by activating the p53 tumor suppressor pathway. Activation of p53 could impair a productive viral infection at many levels, including the inhibitio...

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Adenovirus overrides cellular checkpoints for protein translation.

Modulation of the ARF-p53 pathway by the small DNA tumor viruses.