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A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors.

Horng Ou Kwiatkowski, W Deerinck, Tj Noske, A Blain, Ky Land, Hs Soria, C Powers, Cj May, Ap Shu, X ...

Published in Cell

Evolution of minimal DNA tumor virus genomes has selected for small viral oncoproteins that hijack critical cellular protein interaction networks. The structural basis for the multiple and dominant functions of adenovirus oncoproteins has remained elusive. E4-ORF3 forms a nuclear polymer and simultaneously inactivates p53, PML, TRIM24, and MRE11/R...

Viral and Cellular Genomes Activate Distinct DNA Damage Responses.

Shah, Ga Clodagh O'Shea

Published in Cell

In response to cellular genome breaks, MRE11/RAD50/NBS1 (MRN) activates a global ATM DNA damage response (DDR) that prevents cellular replication. Here, we show that MRN-ATM also has critical functions in defending the cell against DNA viruses. We reveal temporally distinct responses to adenovirus genomes: a critical MRN-ATM DDR that must be inacti...

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A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors.

Viral and Cellular Genomes Activate Distinct DNA Damage Responses.